Hydrogen Peroxide → HCID 14501164, compound

Participants

Reaction Steps

To 0.8 g of 5-morpholino-8-quinolinecarbonitrile (Compound No. 13) 60 ml of methanol was added and the mixture was stirred at 0° C. with further addition of an aqueous solution of 0.47 g of potassium hydroxide and then 5 ml of 30% hydrogen peroxide aqueous solution. The mixture was heated at 40° to 50° C. for 16 hours with stirring. After evaporation of the solvent, saturated sodium chloride aqueous solution was added to the residue, which was extracted with chloroform, and the extract was dried over anhydrous sodium sulfate. Chloroform was evaporated, and the residue was refined by column chromatography on silica gel using chloroform as an eluent. The crystals thus obtained were recrystallized from ethanol to yield 0.48 g (yield: 56%) of 5-morpholino-8-quinolinecarboxamide (Compound No. 22).

Provenance & Evidence