Dimethylformamide → HCID 178473788, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 12.1 g of 1-acetyl-4-(2,4-difluorobenzoyl)-piperidine hydrazone, 11.8 g of potassium carbonate and 120 ml of dimethylformamide was stirred and heated at 120° C. for 16 hrs. The reaction mixture was poured into water and the aqueous solution was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate and the solvent concentrated to give a solid. Recrystallization of the solid from ethyl acetate (twice) yielded 4.1 g (42% with concentration of mother liquor) of product, mp 162°-164° C.

Provenance & Evidence