Hydrazine hydrate (1:1) → HCID 178419304, compound

Participants

Reaction Steps

A mixture of 9.6 g of 1-acetyl-4-(4-bromo-2-fluorobenzoyl)-piperidine and 50 ml of hydrazine hydrate was stirred in an autoclave at 135°-140° C. for 20 hr. The reaction mixture was quenched with water and the solid was collected. The solid was recrystallized from acetonitrile (charcoal) to yield 2.6 g (32%) of product, mp 163°-165° C.

Provenance & Evidence