HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2107480Generated: October 30, 2026
Sodium Iodide → 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/2107480
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride | HCID 11521711 | — |
| Reactant | 3-(4-Bromobutyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone | HCID 21706603 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone hydrochloride | HCID 14856149 | 46.5% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone (3.20 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (2.81 g), K2CO3 (4.83 g) and NaI (250 mg) in acetonitrile (280 ml) was heated at 70° C. for 15 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.30 g of crystals, m.p. 188°-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04933453 |
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| Source dataset | uspto-grants-1990_06 |
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| ORD ID | ord-aeeecec19c2b49b794ba9e47f89449f8 |
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| Source note | uspto-grants-1990_06 |
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