HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2107484Generated: October 29, 2026
Sodium Iodide → 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-2,5,5-trimethyl-4-thiazolidinone hydrochloride
https://huagongshe.com/reaction/2107484
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Chloro-1,2-benzisothiazol-3-yl piperazine | HCID 10491125 | — |
| Reactant | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-[4-[1-(6-Chloro-1,2-benzisothiazol-3-yl)-4-piperazinyl]butyl]-2,5,5-trimethyl-4-thiazolidinone hydrochloride | HCID 14856154 | 132.1% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (3.6 g), 6-chloro-1,2-benzisothiazol-3-yl piperazine (3.7 g), K2CO3 (4.0 g) and NaI (200 mg) in CH3CN (175 ml) was heated at 80° C. for 18 hours and the product was processed in substantially the same manner as in Example 10 to afford 4.714 g of product, m.p. 204°-206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04933453 |
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| Source dataset | uspto-grants-1990_06 |
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| ORD ID | ord-67578db00b4143b19afe2c10e70d268e |
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| Source note | uspto-grants-1990_06 |
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