HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium fluoride → 5-Chloro-2,3-difluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | 2,5-Dichloro-3-fluoropyridine | HCID 10964877 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | 5-Chloro-2,3-difluoropyridine | HCID 2783248 | — |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
A suspension of 64.6 g (1.1 mol) of potassium fluoride and 11.25 g (0.075 mol) of cesium-fluoride in 240 ml of sulfolane (1,1-dioxo-tetrahydrothiophene) is heated to 140° C. By reducing the pressure 50 ml of sulfolane are distilled off. To the suspension a solution of 61.4 g (0.37 mol) of 2,5-dichloro-3-fluoropyridine in 20 ml of sulfolane is added.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04935051 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-5a7eb30cbc33476ea4165e85d234d272 |
| Source note | uspto-grants-1990_06 |