反应详情

温度

80 °C

3.45 g of 4-(2,3-epoxypropoxy)-1H-indole-2-carboxamide and 4.70 g of 1-((4-difluoromethoxyphenyl)phenylmethyl)piperazine are dissolved at 40° C. in 75 ml of methanol. The mixture is then concentrated to dryness in vacuo, the syrupy residue is heated at 80° C. for 15 minutes and, after cooling, the solidified product is triturated with hexane and filtered off with suction.

1. concentrationThe mixture is then concentrated to dryness in vacuo
2. temperatureafter cooling
3. customthe solidified product is triturated with hexane
4. filtrationfiltered off with suction