HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-2-carboxamide, 4-(oxiranylmethoxy)- → HCID 21612015, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-2-carboxamide, 4-(oxiranylmethoxy)- | HCID 4172349 | — |
| Reactant | HCID 21612014 | HCID 21612014 | — |
| Product | HCID 21612015 | HCID 21612015 | — |
Reaction Steps
4-(2,3-Epoxypropoxy)-1H-indole-2-carboxamide is reacted with 1-((4-(2-methoxyethoxy)phenyl)phenylmethyl)piperazine to give 4-(3-(4-((4-(2-methoxyethoxy)phenyl)phenylmethyl)piperazin-1-yl)-2-hydroxypropoxy)-1H-indole-2-carboxamide. The compound obtained is reacted with trifluoroacetic anhydride in a mixture of dioxane and pyridine to give 4-(3-(4-((4-(2-methoxyethoxy)phenyl)phenylmethyl)piperazin-1-yl)-2-hydroxypropoxy)-1H-indole-2-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04935414 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-d70ff162ce1345ca8f0406f39fd7a8d6 |
| Source note | uspto-grants-1990_06 |