Iodine → HCID 14839507, compound

Participants

Reaction Conditions

Reaction Steps

Iodine, 6.34 g, is added in small portions to a mixture of 6 g of 6-[4-(2-pyrimidinyl)-1-piperazinyl]-2-hexanone (Example A) and 3.8 g of thiourea. The resulting paste is heated at 110° C. overnight. The mixture is taken up into boiling water, filtered, and basified with ammonium hydroxide. Dichloromethane is used to extract the products which are purified by silica gel chromatography to afford 2 g of recovered starting ketone, 0.8 g of 4-methyl-5-[3-[4-(2-pyrimidinyl)-1-piperazinyl]propyl]-2-thiazolamine (Example 1); mp 152°-156° C.; and 1.2 g of 4-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2-thiazolamine (Example 1a); mp 101°-104° C.

Provenance & Evidence