1-(2-Pyridyl)piperazine → HCID 14839515, compound

Participants

Reaction Steps

A mixture of 5.84 g of 5-(2-chloroethyl)-2thiazolamine, monohydrochloride (Example C), and 5.27 g of 1-(2-pyridyl)piperazine in 100 ml of dimethylformamide containing 12.3 g of sodium bicarbonate is stirred at 80°-90° C. for 18 hours. The mixture is filtered and the filtrate concentrated to dryness. Chromatography (medium-pressure liquid chromatography, silica gel, 5% methanol-95% chloroform) of the resulting oil affords 5-[2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]-2-thiazolamine as a tan solid; mp 158°-161° C.

Provenance & Evidence