HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 14839498, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| Reactant | HCID 14974707 | HCID 14974707 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 14839498 | HCID 14839498 | 57.2% |
Reaction Steps
A solution of 17.9 g of 6-bromo-4-hexanone and 23.7 g of 1-(2-pyrimidinyl)piperazine dihydrochloride in 500 ml of ethanol and 100 ml of dimethylformamide containing 42 g of sodium bicarbonate is refluxed for 12 hours. The mixture is filtered through Celite, evaporated in vacuo, and the residue chromatographed over silica gel to give 15 g of 6-[4-(2-pyrimidinyl)-1-piperazinyl]-2-hexanone; mp 44°-47° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04935424 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-05c6caecca2f414abb0b69addb4852f0 |
| Source note | uspto-grants-1990_06 |