Thionyl Chloride → HCID 15692419, compound

Participants

Reaction Conditions

Reaction Steps

To ethyl 1-cyclopropyl-7-morpholino-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylate (80 mg) is added thionyl chloride (1 ml), and the mixture is stirred at room temperature for 4 hours and further at 50° C. for one hour. The solvent is concentrated under reduced pressure to give crude ethyl 1-cyclopropyl-7-morpholino-6-fluoro-8-chloromethyl-1,4-dihydro-4-oxoquinoline-3-carboxylate (84 mg).

Provenance & Evidence