反应详情

2,3,6-Trifluoro-1-ethylbenzene (1.09 g) is dissolved in conc. sulfuric acid (5.5 ml), and thereto is added with stirring a mixture of potassium nitrate (0.83 g) in conc. sulfuric acid (4 ml) at room temperature, and the mixture is stirred at the same temperature for one hour. The reaction mixture is poured into cold water (100 ml) and is extracted with diethyl ether. The ether layer is washed with aqueous saturated sodium chloride and dried over magnesium sulfate and then concentrated under reduced pressure to give 3-ethyl-2,4,5-trifluoro-nitrobenzene (1.14 g), as yellow oil.

1. additionis added
2. stirringthe mixture is stirred at the same temperature for one hour
3. extractionis extracted with diethyl ether
4. washThe ether layer is washed with aqueous saturated sodium chloride
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure