Ammonia → HCID 23046142, compound

Participants

Reaction Steps

6-Butyrylthieno[3,2-b]pyridin-7(4H)-one (7.9 g, 0.0357 mol) and phosphorus oxychloride (30 ml) were heated under reflux for 1 hour. After allowing to cool the reaction mixture was poured onto ice basified with concentrated ammonia solution and extracted with dichloromethane (3×150 ml). The combined dichloromethane extracts were dried, filtered and evaporated to dryness to give 6-butyryl-7-chlorothieno[3,2-b]pyridine, 5.5 g. Recrystallization from hexane gave an analytically pure sample, m.p. 78°-80°.

Provenance & Evidence