Hydrochloric Acid → HCID 23046249, compound

Participants

Reaction Steps

2-(2-Carbomethoxyethylthio)-1-(3,5-difluorobenzyl)imidazole (3.12, 0.010 mole) is stirred with 2.5N aqueous sodium hydroxide (20 ml) and the reaction mixture is heated at reflux for one hour and then cooled and neutralized with concentrated hydrochloric acid. The mixture is then extracted three times with ether and the combine ether extracts are concentrated. A crystalline solid is obtained by trituration of the residue with boiling hexane. This is recrystallized from ethyl acetate-hexane to give 2-(2-carboxyethylthio)-1-(3,5-difluorobenzyl)imidazole.

Provenance & Evidence