HRID2107656

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6033189

未命名化合物

结构：CCOC(=O)C(=Cc1ccccc1Cl)C(=O)c1ccc(-n2nc(C)nc2C)cc1

HCID67915387

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1=C(c2ccc(-n3nc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl

HCID15005343

未命名化合物

收率 6.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of the product from step (a) (566 mg, 1.38 mol) and N-(2-pyridyl)-3-aminocrotonamide (245 mg, 1.38 mmol) in ethanol (10 ml) was heated at reflux under nitrogen for 8 hours. The solvent was removed and the residue purified by flash chromatography (eluting with 2% diethylamine in ethyl acetate) to afford the title compound (50 mg, 6%) as a white solid, m.p. 130° C.

WORKUP

后处理

temperaturewas heated
temperatureat reflux under nitrogen for 8 hours
customThe solvent was removed
customthe residue purified by flash chromatography (eluting with 2% diethylamine in ethyl acetate)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6f91833184cc4a94896c59c8ec39dcd4
来源数据集: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04935430
来源说明: uspto-grants-1990_06

反应 SMILES

[CH3:1][C:2]1[N:6]=[C:5]([CH3:7])[N:4]([C:8]2[CH:29]=[CH:28][C:11]([C:12]([C:14](=[CH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[Cl:27])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=O)=[CH:10][CH:9]=2)[N:3]=1.[N:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[NH:36][C:37](=[O:42])/[CH:38]=[C:39](\[NH2:41])/[CH3:40]>C(O)C>[Cl:27][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[CH:20]1[C:38]([C:37](=[O:42])[NH:36][C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][N:30]=2)=[C:39]([CH3:40])[NH:41][C:12]([C:11]2[CH:28]=[CH:29][C:8]([N:4]3[C:5]([CH3:7])=[N:6][C:2]([CH3:1])=[N:3]3)=[CH:9][CH:10]=2)=[C:14]1[C:15]([O:17][CH2:18][CH3:19])=[O:16]