Dimethylformamide → HCID 13393785, compound

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Reaction Steps

As in example 1, but using 10 g 6-fluoro-flavanone, 100 ml dimethylformamide and 15 ml phosphorous oxychloride. Reaction time is one hour and a half at 50° C. After hydrolysis a precipitate formed which is filtered, washed with water and dried over phosphorous pentoxyde. The residual solid is recrystallised in hexane and pure yellow crystalline 4-chloro-6-fluoro-3-formyl-flav-3-ene is obtained; m.p. 74°-75° C.

Provenance & Evidence