Dimethylformamide → HCID 13393799, compound

Participants

Reaction Steps

As in example 18, but using 4.3 g 3-phenyl-3-(3-methoxyphenylmercapto)propionic acid, 40 ml dimethylformamide and 15 ml phosphorous oxychloride. After hydrolysis and work-up the residual oil is purified by column chromatography and the best fractions are recrystallized in diisopropylether. Pure 4-chloro-3-formyl-7-methoxy-thioflav-3-ene is obtained as yellow crystals; m.p. 84°-87° C.

Provenance & Evidence