Dimethylformamide → HCID 13393800, compound

Participants

Reaction Steps

As in example 18,but using 4.3 g 3-phenyl-3-(2-methoxyphenylmercapto)propionic acid, 40 ml dimethylformamide and 15 ml phosphorous oxychloride. After hydrolysis and work-up the residual oil is filtered over a small silicagel column and the residual solid is recrystallized in a mixture of hexane and ethyl acetate. Pure 4-chloro-3-formyl-8-methoxy-thioflav-3-ene is obtained as yellow crystals; m.p. 128°-130° C.

Provenance & Evidence