Dimethylformamide → HCID 13393801, compound

Participants

Reaction Steps

As in example 18, but using 4.6 g 3-(4-fluorophenyl)-3-phenylmercapto-propionic acid, 40 ml dimethylformamide and 15 ml phosphorous oxychloride. After hydrolysis and work-up a residual oil is obtained which is purified by preparative HPLC. The oily fractions are crystallized in hexane and pure 4-chloro-4'-fluoro-3-formyl-thio-flav-3-ene is obtained as yellow crystals; m.p. 67°-69° C.

Provenance & Evidence