Dimethylformamide → HCID 13393802, compound

Participants

Reaction Steps

As in example 18, but using 5.4 g 3-(2-fluorophenyl)-3-phenylmercapto-propionic acid, 40 ml dimethylformamide and 15 ml phosphorous oxychloride. After hydrolysis a precipitate forms which is filtered, washed with water and dried over phosphorous pentoxide. The residual solid is recrystallized in hexane and pure yellow crystalline 4-chloro-2'-fluoro-3-formyl-thioflav-3-ene is obtained; m.p. 119°-120° C.

Provenance & Evidence