Thionyl Chloride → HCID 19349446, compound

HRID 2107768Notes

Reaction equation

HRID 2107768 reaction equation
O[CH2:2][C:3]1[CH:4]=[C:5]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])[CH:6]=[C:7]([CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:8]=1.S(Cl)([Cl:22])=O>ClCCl>[ClH:22].[Cl:22][CH2:2][C:3]1[CH:4]=[C:5]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])[CH:6]=[C:7]([CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19349435HCID 19349435, compound

Product 1

HCID 19349446HCID 19349446, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product from Example 27 (1 g) and thionyl chloride (0.4 ml) in dichloromethane (5 ml) was heated under reflux for 0.5 h, then evaporated to dryness under reduced pressure, to give 2-[3-chloromethyl-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile hydrochloride, mp. 189°-190° after trituration with ethyl acetate.

Workup

  1. temperatureunder reflux for 0.5 h
  2. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-4d58e4c56d4b4f74b3e4321cd2b5797c
Source dataset
uspto-grants-1990_06
Patent number
US04935437

Reaction notes

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