Potassium Carbonate → HCID 88605402, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled solution of the product of Procedure 7 (34.4 g, 52.8 mmol) and well-milled K2CO3 (7.24 g, 52.8 mmol) in dry DMF (344 ml) was added 1-acetoxyethyl bromide (17.64 g, 105.6 mmol) at 0° C. under argon and the mixture was stirred at about 5° C. for 65 min. The reaction mixture was poured into ice-water (1720 ml) with stirring adjusted to pH 7 with aq. NaHCO3 solution, and stirred for 30 min. The resulting precipitate was collected, washed with water (100 ml) and dried to give 37.61 g of the desired product (97%, purity 80%) as an amorphous powder.

Provenance & Evidence