Thionyl Chloride → HCID 19817494, compound

HRID 2107863Notes

Reaction equation

HRID 2107863 reaction equation
[ClH:1].[N:2]1([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:16])=O>>[ClH:16].[N:2]1([CH2:8][CH2:9][CH2:10][C:11]([Cl:1])=[O:13])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 131720814-(Piperidin-1-yl)butanoic acid hydrochloride

Product 1

HCID 19817494HCID 19817494, compound

Procedure

4-Piperidinobutyric acid hydrochloride (750 mg) and 4 ml of thionyl chloride were combined and stirred at reflux for 45 min., concentrated, triturated with ether and dried to give 700 mg of light brown solid which when dissolved in dry methanol gave Rf 0.1 in system D, distinctly different from the starting acid and presumably the methyl ester. The solid was used without further purification.

Workup

  1. temperatureat reflux for 45 min.
  2. concentrationconcentrated
  3. customtriturated with ether
  4. customdried

Sources & evidence

ORD record
ord-1dbded503f4d4818a907f3a97c717687
Source dataset
uspto-grants-1990_06
Patent number
US04935405

Reaction notes

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