HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[tert-butoxycarbonyl]-L-serine → N-[(1,1-Dimethylethoxy)carbonyl]-O-methyl-L-homoserine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[tert-butoxycarbonyl]-L-serine | HCID 98766 | — |
| Reactant | (2S)-2-(((tert-butoxy)carbonyl)amino)-4-hydroxybutanoic acid | HCID 13066457 | — |
| Product | N-[(1,1-Dimethylethoxy)carbonyl]-O-methyl-L-homoserine | HCID 15058461 | — |
Reaction Steps
Boc-homoserine (0.51 g) was methylated as described for Boc-serine in Example 73. This afforded 0.45 g crude product which was carried on without further purification. NMR (300 MHz, CDCl3) delta 1.40 (s, 9H), 3.16 (s, 3H), 3.90 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04935405 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-cdd7acd4b1954eb9a54b15b05bc233cb |
| Source note | uspto-grants-1990_06 |