HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester | HCID 15058496 | 14.3% |
Reaction Steps
Ethyl 2-bromo-3-phenylpropionate (1.95 g) was treated with 3.05 g N-methylpiperazine as described in Example 95 to afford 0.30 g pure product after chromatography (9:1 CH2Cl2 :MeOH). NMR (300 MHz, CDCl3) delta 1.10 (d, J=7 Hz, 3H), 2.26 (s, 3H), 3.37 (m, 1H), 4.00 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04935405 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-6516543106bd40c08c9d4e2ba66455cb |
| Source note | uspto-grants-1990_06 |