HCID 10534915, compound → HCID 15924948, compound

Participants

Reaction Steps

A mixture of 3.10 g of methyl α-(hexahydro-2-pyridinylidene)acetate and 10 ml of xylene was gently refluxed, to which a solution of 7.81 g of 2-ethyl-2,6-dimethyl-4H-1,3-dioxin-4-one in 10 ml of xylene was dropwise added, taking 20 minutes. The mixture was further refluxed for 2 hours, removing the by-product a methyl ethyl ketone through Dean-Stark apparatus. The reaction mixture was cooled to room temperature. The resultant crystals were filtered, washed and dried under reduced pressure to obtain 4.11 g (Yield 93%) of methyl 6,7,8,9-tetrahydro-4-methyl-2-oxo-2H-quinolizine-1-carboxylate.

Provenance & Evidence