Sodium Carbonate → HCID 15924938, compound

Participants

Reaction Steps

A mixture of 0.11 ml of bromine and 8 ml of methylene chloride was dropwise added to a mixture of 0.70 g of N-(2,6-diethylphenyl)-6,7,8,9-tetrahydro-4-methyl-2-oxo-2H-quinolizine-1-carboxamide, 1.27 g of sodium carbonate and 12 ml of methylene chloride at room temperature taking 30 minutes and further stirred for 5 hours at room temperature. After filtering the insoluble material off, the solution was concentrated and the resulting crystalline residue was recrystallized from a mixture of ethyl acetate and methanol to afford 0.64 g (Yield 75%) of the title compound.

Provenance & Evidence