2,2,6-Trimethyl-4H-1,3-dioxin-4-one → HCID 14801608, compound

Participants

Reaction Steps

A mixture of 20.0 g of methyl α-(hexahydro-2-azepinylidene)acetate and 77 ml of xylene was gently refluxed, to which a mixture of 41.9 g of 2,2,6-trimethyl-4H-1,3-dioxin-4-one and 41 ml of xylene was dropwise added taking 45 minutes and refluxed for 2 hours, removing the by-product acetone through a Dean-Stark apparatus. The reaction mixture was cooled to room temperature. The resulting crystals were filtered, washed and dried to afford 21.4 g (Yield 77%) of methyl 2,6,7,8,9,10-hexahydro-4-methyl-2-oxo-pyrido[1,2-a]azepine-1-carboxylate.

Provenance & Evidence