Nitric Acid → HCID 14421353, compound

HRID 2107878Notes

Reaction equation

HRID 2107878 reaction equation
C(OC(=O)C)(=O)C.[N+:8]([O-:11])(O)=[O:9].[C:12]([NH:15][C:16]1[N:20]([C:21]2[C:26]([F:27])=[CH:25][C:24]([C:28]([F:31])([F:30])[F:29])=[CH:23][C:22]=2[Cl:32])[N:19]=[CH:18][CH:17]=1)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([NH:15][C:16]1[N:20]([C:21]2[C:26]([F:27])=[CH:25][C:24]([C:28]([F:30])([F:31])[F:29])=[CH:23][C:22]=2[Cl:32])[N:19]=[CH:18][C:17]=1[N+:8]([O-:11])=[O:9])(=[O:14])[CH3:13]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 7918Acetic AnhydrideHCID 14421351HCID 14421351, compound

Product 1

HCID 14421353HCID 14421353, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2 ml (0.021 mol) of acetic anhydride and 0.9 ml (0.02 mol) of 98% strength nitric acid are successively added to 6 g (0.019 mol) of 5-acetamido-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole in 15 ml of glacial acetic acid at room temperature, and the mixture is stirred at room temperature for 15 hours. For working-up, the reaction mixture is added dropwise to 200 ml of ice-water, and the precipitate formed is filtered off, washed with water and dried in vacuo at 50° C. 5.8 g (85% of theory) of 5-acetamido-4-nitro-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazole of melting point 129°-130° C. are obtained.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried in vacuo at 50° C

Sources & evidence

ORD record
ord-3a2020e8df5e440dacbb9551b8c14bed
Source dataset
uspto-grants-1990_06
Patent number
US04936892

Reaction notes

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