2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → HCID 14421338, compound

Participants

Reaction Steps

200 g (0.88 mol) of 2-chloro-6-fluoro-4-trifluoromethylphenylhydrazine and 151 g (0.88 mol) of ethyl ethoxymethylenecyanoacetate in 400 ml of ethanol are heated to the reflux temperature for 30 hours, the mixture is then concentrated to approximately half of the volume and cooled and the precipitate thus obtained is filtered off, washed with a little cold ethanol and dried. 250 g (81% of theory) of ethyl 5-amino-1-(2-chloro-6-fluoro-4-trifluoromethylphenyl)-pyrazol-4-yl carboxylate of melting point 147°-149° C. are obtained.

Provenance & Evidence