HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Diketene | HCID 12661 | — |
| Reactant | Ethyl 3-(methylamino)-3-phenylacrylate | HCID 58005139 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate | HCID 14075276 | — |
Reaction Steps
10.25 gms of ethyl beta-methylaminocinnamate, 9.4 gms of technical grade diketene and 25 mls dry methylene chloride are mixed in a flask fitted with a calcium chloride drying tube. The reaction mixture is stored at room temperature for 117 hours. Approximately 75 ml of dry ether is added and the resulting crystalline solid is filtered to yield 8.5 gms of ethyl 1,6-dimethyl-2-phenyl-4-oxonicotinate. mp (toluene)=244-8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04936904 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-13d7d4127eef481a975d0ab059db46d1 |
| Source note | uspto-grants-1990_06 |