Diketene → HCID 14075281, compound

Participants

Reaction Steps

4.64 gms of ethyl beta-ethylamino-4-chlorocinnamate, 4.61 gms of technical grade diketene and 15 mls of methylene chloride are mixed in a flask fitted with a calcium chloride drying tube. The mixture is maintained at room temperature for 137 hours. The methylene chloride is removed in vacuo and the residue triturated with ether to yield 3.2 gms of crude ethyl 1-ethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinate. mp (215-17).

Provenance & Evidence