HCID 22159900, compound → HCID 14075283, compound

HRID 2107896Notes

Reaction equation

HRID 2107896 reaction equation
[C:1]([CH2:4][N:5]1[C:13]([CH3:14])=[CH:12][C:11](=[O:15])[C:7]([C:8]([O-:10])=[O:9])=[C:6]1[C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)([OH:3])=[O:2]>[OH-].[Na+]>[C:1]([CH2:4][N:5]1[C:13]([CH3:14])=[CH:12][C:11](=[O:15])[C:7]([C:8]([OH:10])=[O:9])=[C:6]1[C:16]1[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=1)([OH:3])=[O:2]

Participants

3

Reactant 1

HCID 22159900HCID 22159900, compound

Product 1

HCID 14075283HCID 14075283, compoundYield 72.3%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

4.0 gms of 1-carboxymethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinate is suspended in 40 gms of 5% aqueous sodium hydroxide solution and heated at 80°-85° for two hours. The reaction mixture is cooled and acidified to give a white precipitate. This precipitate is collected by filtration to yield 2.9 gms of 1-carboxymethyl-6-methyl-2-(4'-chlorophenyl)-4-oxonicotinic acid. mp (CH3CN)=158-62.

Workup

  1. temperatureheated at 80°-85° for two hours
  2. temperatureThe reaction mixture is cooled
  3. customto give a white precipitate
  4. filtrationThis precipitate is collected by filtration

Sources & evidence

ORD record
ord-9ee11842e7ba443883fe9ebdee6c8f13
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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