Sodium Hydroxide → HCID 14075318, compound

HRID 2107901Notes

Reaction equation

HRID 2107901 reaction equation
Cl.[CH3:2][N:3]1[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:12][C:11](=[O:20])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]1[CH3:21].[OH-].[Na+]>O>[CH3:2][N:3]1[C:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:12][C:11](=[O:20])[C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[C:4]1[CH3:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14075319HCID 14075319, compound

Product 1

HCID 14075318HCID 14075318, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.0 g (0.0065 mol.) of ethyl 1,2-dimethyl-6-phenyl-4-oxonicotinate hydrochloride (see Example 49 below) is dissolved in water and treated with dilute sodium hydroxide (pH adjusted to about 8). The precipitate formed is isolated by vacuum filtration to afford 1.9 g of product, mp 154° C. (MDC/ether recrystallization).

Workup

  1. customThe precipitate formed
  2. customis isolated by vacuum filtration
  3. customto afford
  4. custom1.9 g of product, mp 154° C. (MDC/ether recrystallization)

Sources & evidence

ORD record
ord-676a1450c3dd4ac3b0a315e16f7638b0
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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