Sodium Hydroxide → HCID 23704999, compound

HRID 2107906Notes

Reaction equation

HRID 2107906 reaction equation
[OH-].[Na+:2].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]([CH3:21])[C:12]([CH3:20])=[C:13]([C:17](=[O:19])[CH:18]=2)[C:14]([OH:16])=[O:15])=[CH:6][CH:5]=1>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]([CH3:21])[C:12]([CH3:20])=[C:13]([C:17](=[O:19])[CH:18]=2)[C:14]([O-:16])=[O:15])=[CH:8][CH:9]=1.[Na+:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14075329HCID 14075329, compound

Product 1

HCID 23704999HCID 23704999, compoundYield 87.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.52 g (0.0065 mol) of 50% aqueous sodium hydroxide is added to a suspension of 1.8 g (0.0065 mol) 6-(4-chlorophenyl)-1,2-dimethyl-4-oxonicotinic acid in 35 ml of methanol. The solution formed is allowed to stand at room temperature for 1 hr. and then is concentrated in vacuo. The concentrate is washed with two (25 ml) portions of diethyl ether and dried to afford 1.7 g (87% yield) of product.

Workup

  1. customThe solution formed
  2. concentrationand then is concentrated in vacuo
  3. washThe concentrate is washed with two (25 ml) portions of diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-732b097d671f42d7b8da574baa5b30d0
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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