Sodium Hydroxide → HCID 23673131, compound

HRID 2107908Notes

Reaction equation

HRID 2107908 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH3:19])[C:10]([CH3:18])=[C:11]([C:15](=[O:17])[CH:16]=2)[C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[OH-].[Na+:21]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]([CH3:19])[C:10]([CH3:18])=[C:11]([C:15](=[O:17])[CH:16]=2)[C:12]([O-:14])=[O:13])=[CH:6][CH:7]=1.[Na+:21]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14075339HCID 14075339, compound

Product 1

HCID 23673131HCID 23673131, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2 g (0.0062 mol) of 6-(4-bromophenyl)-1,2-dimethyl-4-oxonicotinic acid is suspended in 50 ml of methanol and to it there is added 0.5 g (0.0062 mol) of 50% aqueous sodium hydroxide. The solution formed is allowed to stand at room temperature for 1 hr. and is concentrated in vacuo. The concentrate is washed with 50 ml of diethyl ether and dried to afford 1.9 g (89% yield) of product.

Workup

  1. customThe solution formed
  2. concentrationand is concentrated in vacuo
  3. washThe concentrate is washed with 50 ml of diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-a1d561c5d283475a8e03d39637795d25
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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