Sodium Hydroxide → HCID 14075353, compound

HRID 2107913Notes

Reaction equation

HRID 2107913 reaction equation
[CH3:1][N:2]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10](=[O:19])[C:4]([C:5]([O:7]CC)=[O:6])=[C:3]1[CH3:20].[OH-].[Na+]>>[CH3:1][N:2]1[CH:12]=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10](=[O:19])[C:4]([C:5]([OH:7])=[O:6])=[C:3]1[CH3:20]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 14075352HCID 14075352, compound

Product 1

HCID 14075353HCID 14075353, compound

Procedure

5.8 g. of ethyl 1,2-dimethyl-5-phenyl-4-oxonicotinate was suspended in 60 ml. of 5% aqueous NaOH solution and heated on a steambath for 21/2 hours. The mixture was cooled and acidified. The resulting solid was recrystallized from acetonitrile to yield 1,2-dimethyl-5-phenyl-4-oxonicotinic acid as tan needles. m.p.=227°-228° C.

Workup

  1. temperatureThe mixture was cooled
  2. customThe resulting solid was recrystallized from acetonitrile

Sources & evidence

ORD record
ord-ab7a3a4d3ba849c8adc2d39c247a85ee
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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