HCID 14075369, compound → HCID 14075370, compound

HRID 2107919Notes

Reaction equation

HRID 2107919 reaction equation
[C:1]1([C:7]2[N:16]([CH3:17])[C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][C:13](=[O:24])[C:8]=2[C:9]([O:11]C)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[OH-].[Na+]>[C:1]1([C:7]2[N:16]([CH3:17])[C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:14][C:13](=[O:24])[C:8]=2[C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 14075369HCID 14075369, compound

Product 1

HCID 14075370HCID 14075370, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

2.5 gms of methyl 2,6-diphenyl-1-methyl-4-oxonicotinate was suspended in 28 mls of 5% aqueous sodium hydroxide 8 hours, cooled, and filtered to remove residual insolubles. The clear basic solution was then acidified with diluted HCl to provide a white precipitate of 2,6-diphenyl-1-methyl-4-oxonicotinic acid. Recrystallization from methylene chloride/ether provided 2.4 gms of product. mp=209°-11°(dec).

Workup

  1. temperaturecooled
  2. filtrationfiltered
  3. customto remove residual insolubles

Sources & evidence

ORD record
ord-0a02ecb773bb4aa8b7a6152121ce7104
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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