Sodium Hydroxide → HCID 23705009, compound

HRID 2107924Notes

Reaction equation

HRID 2107924 reaction equation
[CH3:1][N:2]1[C:10]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:9][C:8](=[O:18])[C:4]([C:5]([OH:7])=[O:6])=[C:3]1[C:19]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=1.[OH-].[Na+:27]>CO>[CH3:1][N:2]1[C:10]([C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)=[CH:9][C:8](=[O:18])[C:4]([C:5]([O-:7])=[O:6])=[C:3]1[C:19]1[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=1.[Na+:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14075374HCID 14075374, compound

Product 1

HCID 23705009HCID 23705009, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.45 gms of 1-methyl-2,6-di(4'-fluorophenyl)-4-oxonicotinic acid was mixed with 0.445 gms of NaOH and 70 mls of methanol. Evaporation of the solvent provided 3.1 gms of sodium 1-methyl-2,6-di(4'-fluorophenyl)-4-oxonicotinate as a glassy solid.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-9e1e202a636c42188e184db7f3aa7a17
Source dataset
uspto-grants-1990_06
Patent number
US04936904

Reaction notes

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