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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2107937Generated: October 29, 2026

Phosphorus oxychloride → HCID 19776311, compound

https://huagongshe.com/reaction/2107937

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantN-(5-Hydroxypentyl)trifluoroacetamideHCID 4459265—
ProductHCID 19776311HCID 19776311—

Reaction Steps

3',5'-Bis-(5-aminopentylphosphoryl)-thymidine of step 7 may also be prepared by reacting 5-trifluoroacetamido-pentanol with phosphoryl chloride, forming 5-trifluoroacetamidopentylphosphorodichloridite, that can be reacted in pyridine with thymidine followed by hydrolysis in aqueous piperidine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04937188
Source datasetuspto-grants-1990_06
ORD IDord-1e96ff7511eb41639c3de712537ef183
Source noteuspto-grants-1990_06