HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → HCID 23044998, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | 1-(4,4-Bis(4-fluorophenyl)butyl)piperazine | HCID 79729 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23044998 | HCID 23044998 | 65.6% |
Reaction Steps
8.3 g (0.025 mole) of 1-[4,4-bis(p-fluorophenyl)butyl]-piperazine and 3.1 g (0.027 mole) of 2-chloropyrimidin were heated in 5 ml DMF at 150° C. until TLC showed the disappearance of the starting piperazine derivative. After cooling EtOAc (50 ml) and EtOH (enough to get a clear solution) were added. Ether was added, whereby the desired product crystallized. Recrystallization from EtOH, EtOAc+ether yielded 7.3 g (65%) of the title compound (2:1), m.p. 195°-97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04937245 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-6ffeffc372844803904d8950ef8d6f88 |
| Source note | uspto-grants-1990_06 |