3-Nitrobenzaldehyde → HCID 15718252, compound

Participants

Reaction Steps

1.6 g of m-nitrobenzaldehyde, 3.7 g of 3-[4-(tert-butyloxycarbonyl)-1-piperazinyl]-2,2-dimethylpropyl acetoacetate, and 1.3 g of methyl 3-aminocrotonate were dissolved in 10 ml of isopropanol, and the solution was subjected to heating reflux for 12 hours. Then, the solvent was concentrated under reduced pressure. Diethyl ether was added to the residue to give 2.7 g of a colorless powdery crystal (yield: 44%). The IR and NMR data of the compound thus obtained are as follows: ##STR14##

Provenance & Evidence