HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (Racemic)-N-[4-[3-(Acetyloxy)-1-pyrrolidinyl]-2-butynyl]-N-methyl acetamide | HCID 15086787 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]- | HCID 536669 | 73.2% |
Reaction Steps
A mixture of 820 mg of (racemic)-N-[4-[3-(acetyloxy)-1-pyrrolidinyl]-2-butynyl]-N-methyl acetamide, 635 mg of sodium carbonate and 40 ml of methanol was stirred overnight. An equal volume of dichloromethane was added, the mixture filtered and the solvents concentrated. This residue was purified by chromatography (alumina), giving 500 mg of the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04937235 |
| Source dataset | uspto-grants-1990_06 |
| ORD ID | ord-c7ae12738e334b13a5dd19a0ecc86d49 |
| Source note | uspto-grants-1990_06 |