反应详情

To a mixture of 3-(4-methylbenzoyl)propionic acid (7.5 g) and methylene chloride (250 ml) was added slowly portionwise aluminum chloride (15 g) at 0° C. After the addition was completed chlorine gas was bubbled in slowly at 0° C. After 6 hours the reaction mixture was poured into a mixture of hydrochloric acid and ice and extracted with methylene chloride (3×150 ml), the combined organic layers were washed with water, dried and evaporated under vacuum yielding 3-(3,5-dichloro-4-methylbenzoyl)propionic acid as a yellow solid (4.5 g).

1. additionAfter the addition
2. customwas bubbled in slowly at 0° C
3. additionAfter 6 hours the reaction mixture was poured into a mixture of hydrochloric acid and ice
4. extractionextracted with methylene chloride (3×150 ml)
5. washthe combined organic layers were washed with water
6. customdried
7. customevaporated under vacuum