Diphenyl carbonate → HCID 23045101, compound

HRID 2108006Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][NH:9][CH2:10][CH2:11][SH:12].[C:13](=O)(OC1C=CC=CC=1)[O:14]C1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[CH2:10][CH2:11][S:12][C:13]1=[O:14]

Participants

Reactant 2

HCID 7597Diphenyl carbonate

HCID 23045099HCID 23045099, compound

Product 1

HCID 23045101HCID 23045101, compoundYield 43.9%

Procedure

The procedure of Example 2 is followed 5.05 g (0.025 mol) of N-(2-chlorophenylmethyl)cysteamine are reacted with 5.35 g (0.025 mol) of diphenyl carbonate and then worked up. The product is purified by column chromatography (by using Kieselgel 60 of 230-400 mesh as sorbent and chloroform as eluent) to obtain 2.5 g (43.9%) of the title compound, nD30 =1.600.

Workup

customThe product is purified by column chromatography (by using Kieselgel 60 of 230-400 mesh as sorbent and chloroform as eluent)

Sources & evidence

ORD record: ord-3703e6de5dc4490c9d172eb378352d38
Source dataset: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04937252

Reaction notes

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