HCID 15029755, compound → HCID 14231165, compound

HRID 2108015Notes

Reaction equation

HRID 2108015 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)(O)[CH:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1>S(Cl)(Cl)=O>[CH3:32][O:31][C:28]1[CH:29]=[CH:30][C:25]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:12]=[CH:13][C:14]([C:17]#[N:18])=[CH:15][CH:16]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 15029755HCID 15029755, compound

Product 1

HCID 14231165HCID 14231165, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

2,2-Bis-(4-methoxyphenyl)-2-hydroxy-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethane (10.2 g) is dissolved in thionyl chloride (25 mL) and the solution is stirred at room temperature for 36 hours. The solvent is evaporated and the residue is chromatographed on silica gel (250 g). Elution with ethyl acetate affords the crystalline 2,2-bis-(4-methoxyphenyl)-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethylene. The compound has m.p. 174°-176° after recrystallization from isopropanol.

Workup

  1. customThe solvent is evaporated
  2. customthe residue is chromatographed on silica gel (250 g)
  3. washElution with ethyl acetate

Sources & evidence

ORD record
ord-09e2cd848f644dfa8c3ba806e5d142a1
Source dataset
uspto-grants-1990_06
Patent number
US04937250

Reaction notes

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