Carbon tetrabromide → HCID 23045078, compound

Participants

Reaction Steps

Triphenylphosphine (2.89 g) in dichloromethane (20 ml) was added dropwise to a solution of 6-[3-(2-pyridinyl)propoxy]-4-hexyn-1-ol (2.33 g) and carbon tetrabromide (3.65 g) in dichloromethane (30 ml) cooled in an ice-bath. The reaction mixture was stirred at room temperature for 1 h, the solvent was evaporated and the residue was purified by FCC eluting with hexane-ether (1:1) to give the title compound as an orange oil (2.0 g), t.l.c. (hexane-ether 1:1) Rf 0.2.

Provenance & Evidence