Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromo-3-methoxypyridine → HCID 23045060, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromo-3-methoxypyridine | HCID 90364 | — |
| 반응물 | 4-Amino-3,5-dichloro-alpha-[[(phenylmethyl)[6-[(2-propynyl)oxy]hexyl]amino]methyl]benzenemethanol | HCID 20062846 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Diethylamine | HCID 8021 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 23045060 | HCID 23045060 | 77.7% |
반응 단계
A solution of 2-bromo-3-methoxypyridine (2 g), 4-amino-3,5-dichloro-α-[[(phenylmethyl)[6-[(2-propynyl)oxy]hexyl]amino]methyl]benzenemethanol (5.74 g), BTPC (150 mg), copper (I) iodide (15 mg) in diethylamine (20 ml) and THF (10 ml) was stirred under nitrogen overnight. The solution was concentrated in vacuo to give a brown oil which was purified by FCC eluting with System C (95:5:1) to give the title compound as a brown oil (4.6 g), t.l.c. (System A 80:20:1) Rf 0.6.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04937251 |
| 출처 데이터셋 | uspto-grants-1990_06 |
| ORD ID | ord-77ec110885904cf684a73fe2a1086a4b |
| 출처 메모 | uspto-grants-1990_06 |