反应详情

A solution of N-[6-[2-(2-pyridinyl)ethoxy]hexyl]benzenemethanamine (2.00 g) in ethanol (10 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (50% paste, 800 mg) in ethanol (120 ml) and hydrogenated at room temperature and pressure. The catalyst was removed by filtration through hyflo and the solvent evaporated in vacuo. The residual oil was purified by FCC eluting with System A (39:10:1→32:17:1) to afford the title compound as a colourless liquid (0.99 g), t.l.c. (System A 39:10:1) Rf 0.16.

1. customThe catalyst was removed by filtration through hyflo
2. customthe solvent evaporated in vacuo
3. customThe residual oil was purified by FCC
4. washeluting with System A (39:10:1→32:17:1)